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Question 0009
Old Posted: 11/7/2011 11:10:29 AM   #1
 
Join Date: 11/6/2011 12:00:00 AM

Default  Gene regulation, mSEC, osteoblast precursors, etc.

Question #0009


mSEC probably:





You answered A - Incorrect

C is correct. mSEC is a protein, so therefore it cannot be A and B. It might have some enzyme function, but since mSEC is extracellular when it reaches the osteoblasts, it has little substrates available. Also, an extracellular protein would not make dNTPS (which need to be intracellular).


The question above is confusing me.  Specifically, it says, "mSEC is a protein, so therefore it cannot be A and B." This doesn't make sense. Protein can bind directly to DNA (see http://en.wikipedia.org/wiki/DNA-binding_protein)

Does anybody know what they mean by "mSEC is a protein, so therefore it cannot be A and B" ?
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Old Posted: 3/19/2013 9:43:37 AM   #2
 
Join Date: 8/7/2011 12:00:00 AM

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Well, proteins cannot directly diffuse through membranes since they are hydrophobic. This is why all peptide hormones need a membrane receptor. It is safe to assume that mSEC would act similarly, if a protein. However, the passage did not explicitly state that mSEC was a protein, so I'm not sure how we were supposed to make that conclusion.
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Old Posted: 4/2/2013 1:51:51 PM   #3
 
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Adam,  I came to the forums with the same question: why is the fact that mSEC is a protein eliminate it from acting on DNA?  DNA binding proteins do exist.  They can bind with sequence specificity and often function in the recruitment of DNAP, RNAP, etc.  Edelaney's comment offers a better explanation: mSEC most likely never enters the cell.  Even if mSEC was a hormone, and did affect transcription, it would most likely do so indirectly.  Look at the peptide-hormone insulin.  It binds to its receptor, which activates a kinase cascade, which eventually ends in transciption alteration.

Edelaney, you're right - the passage never directly states that mSEC is a protein.  I assumed it was, because of the talk of TFs, which are generally proteins.  Since the passage never confirms that mSEC is a protein, the explanation as to why choices A and B are wrong are invalid.
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Old Posted: 4/4/2013 10:03:16 AM   #4
 
Join Date: 4/2/2013 12:00:00 AM

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Not sure if you guys participated in yesterday's question, but it was a continuation of the mSEC passage.  All of our questions were answered :)  Perhaps we have some moderators lurking in the forums...?
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Old Posted: 12/11/2016 1:17:19 AM   #5
 
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Old Posted: 12/15/2016 4:45:19 AM   #6
 
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Default  Gene regulation, mSEC, osteoblast precursors, etc.

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Old Posted: 1/14/2017 2:32:37 PM   #7
 
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Old Posted: 8/24/2017 4:32:30 AM   #11
 
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Old Posted: 9/11/2017 11:29:22 PM   #12
 
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It’s been difficult to accept that I’m often a battleground for several sides of myself, which seem to act in opposition to one another. Is there any solution to feeling so divided? Krishnamurti said, “ In division there is insecurity, in war there is uncertainty. But when the mind sees the danger of division very clearly – not intellectually, not emotionally, but actually sees it – then there is a totally different kind of action.” That new action lies at a level above the yes- and-no level on which we live, and a new attitude can help us find the way to it. The Jungian concept so often mentioned by nike free shoes women nike free 2014 michael kors hamilton bag michael kors shoulder handbag nike?high?heels?sneakers nike free shoes women nike free 2014 mk bags outlet sale michael kors clutch animal print nike sneakers for women nike sneakers air max discount nike shoes outlet Michael Kors Jet Set. Michael Kors Naomi Satchels discount nike shoes online cheapest nike shoes ever Nike Shox R6 cheap michael kors bags Michael Kors Package Deals mk shoulder bags wholesale michael kors crossbody handbags michael kors jet set checkbook wallet michael kors satchel michael kors checkbook wallet black Michael Kors Shoulder Tote nike shoes free Nike Air Jordan 26 Nike Air Jordan Hydro Nike Air Max Command nike sneakers cheap nike women's free 5.0 running shoes coach luggage mens coach satchel clearance coach city zip tote nike sneakers air max nike sneakers cheap coach bags for sale Cheap Nike Shoes Online Marion Woodman suggests we can approach it by “holding the tension of the opposites.” If we can resist the magnetic attraction of one side of any situation long enough to acknowledge both sides, however painful that may be, we rise above division, rather than imprisoning ourselves in it.
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Old Posted: 9/15/2017 1:55:02 AM   #14
 
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